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Many diseases, like cancer or neurodegenerative diseases result from incorrectly processed mRNAs. This project aims to understand mRNA-processing and quality control as well as mRNA transport and translation. By using a variety of different methods, proteins will be identified and characterized that are involved in these processes. Moreover, we study the regulation and the linkage between processing, transport, quality control and translation. We use the budding yeast Saccharomyces cerevisiae as a model organism in which we combined cell biological and biochemical methods with genetics. Additionally we use human cell culture. The studies will lead to a better understanding of gene expression.

 

 

Articles:

 

Hackmann et al. 2011, EMBO-Rep., in press

 

Khoshnevis et al. 2010, EMBO-Rep., 214-219

 

Gross et al. 2007, Science 315, 646-649

 

Reviews:

 

Tutucci and Stutz, 2011, Molecular Cell Biology 12, 377-384

 

Baierlein and Krebber, 2010, RNA-Biology 7, 548-550

 

Huang and Steitz, 2005, Molecular Cell 17, 613-615