加拿大蒙特利尔大学分子生物学博士后招聘
2011-09-07 15:53 来源：未知 作者：颜墨
Job Description
| The Institute for Research in Immunology and Cancer (www.iric.ca) is an ultra-modern research hub and training centre located in the heart of University of Montreal, which was created in 2003 to shed light on the mechanisms of cancer and discover new, more effective therapies to counter this plague. IRIC’s innovative Systems Biology approaches to research has already led to discoveries that will, over the coming years, have a significant impact on the fight against cancer. A postdoctoral position is available in the Laboratory of Intracellular Signaling at IRIC for a highly motivated and talented candidate to study cutting-edge signal transduction mechanisms relevant to the highly oncogenic Ras/MAPK pathway using powerful Drosophila molecular genetics tools in combination with state-of-the-art molecular, structural and biochemical approaches as well as mammalian cell culture systems. Four areas of projects are available: 1) Regulatory mechanisms governing RAF dimerization events; 2) Identification and characterization of small molecule inhibitors of RAF dimerization; 3) Characterization of post-transcriptional events governing steady-state levels of core Ras/MAPK pathway components; 4) Using Drosophila fruit flies as a tool to identify and characterize genes involved in Hox-mediated leukemia. Applicants must hold a PhD degree in a field relevant to biological sciences. Experience with molecular biology techniques, cell culture and protein purification is required, whereas experience with biochemical assays, the ubiquitin/proteasome system and Drosophila genetics would be an asset. First-author publications in internationally-recognized journals during the PhD are expected as well as strong written and oral communication skills. Interested applicants should email a cover letter (describing their research interests and experience), a CV and contact information of three references to marc.therrien@umontreal.ca Further details can be found at: http://www.iric.ca/Recherche/Unites_Recherche/Signalisation_Intra_EN.html Please note that only the selected applicants will be contacted. -- Selected publications Rajakulendran, T., Sahmi, M., Lefrançois, M., Sicheri, F., and Therrien, M. (2009). A dimerization-dependent mechanism drives RAF catalytic activation. Nature 461: 542-6 Ashton-Beaucage, D., Udell, C., Lavoie, H., Baril, C., Lefrancois, M., Chagnon, P., Gendron, P., Caron-Lizotte, O., Bonneil, E., Thibault, P., and Therrien, M. (2010). The Exon Junction Complex controls the splicing of mapk pre-mRNA and other long intron-containing transcripts in Drosophila. Cell 143: 251-62 Udell, C., Rajakulendran, T., Sicheri, F., and Therrien, M. (2011). Mechanistic principles of RAF kinase signaling. Cell Mol Life Sci 68: 553-65 |
| Contact: | Institute for Research in Immunology and Cancer - University of Montreal Montreal, Quebec Canada Email: marc.therrien  umontreal.ca |
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