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Job Description
The European Molecular Biology Laboratory (EMBL) is one of the highest ranked scientific research organizations in the world. The Headquarters Laboratory is located in Heidelberg (Germany) and the outstations are in Grenoble (France), Hamburg (Germany), Hinxton (UK) and Monterotondo (Italy).
The Lemke group at the EMBL studies interactions between intrinsically disordered proteins and structured proteins in vital processes, such as the nuclear transport machinery. Because such highly dynamic systems are inaccessible by most conventional approaches, the group applies a multidisciplinary approach combining single molecule and super resolution techniques with chemical biology tools. Recently the group developed a novel semi-genetic/synthetic strategy that substantially expands our ability to study protein machines both in the test tube and also in cells with extremely high spatial and temporal resolution.
We are now actively looking for a postdoctoral fellow with a strong interest in fluorescent techniques to push the temporal and spatial resolution limit of single molecule/super resolution techniques in biology. The goal is to combine biochemical single molecule FRET techniques with super resolution (such as PALM etc.) studies in cells to gain an unbiased view of the underlying protein plasticity.
Qualifications and Experience:
The project is ideally suited for candidates with a previous background in advanced fluorescence microscopy, single molecule spectroscopy or a related technique and strong skills in quantitative data analysis. However, most important is an interdisciplinary interest and the ability to tackle a biological problem with a combination of techniques, ranging from biochemistry to chemistry to biophysical spectroscopy. Consequently, strong interest and motivation are the main selection criteria and candidates from other disciplines that want to venture into these areas are explicitly welcome to apply.
The group of Dr. Lemke is part of both the Structural and Computational Biology and the Cell Biology and Biophysics Units at the EMBL, featuring a large range of groups spanning various techniques from the molecular to the systems level. Applicants should feel comfortable working in such an interdisciplinary and international environment to fully utilize this unique opportunity. |
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